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Since intercourse seems to be an element differentially related to the lack of closure of specific areas of the neural tube, it would seem to assist the notion that there are several closure websites in the human neural tube. Nevertheless, no affiliation was discovered between selected sex and both the type of NTD which have an isolated abnormality or these NTD related to developmental abnormalities of other physique systems. The findings relating to sex and NTD in a sequence of mid-trimester fetuses are reviewed and then analyzed by way of the current hypothesis that throughout embryogenesis of the human neural tube, there are several closure websites, reasonably than a single zipping up process. Whereas neural tube defects (NTD) generally have a female sex bias, this doesn’t apply to all sites along the neuraxis.

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